Stimulus control along a drug-dose dimension

New Dimension in Drug Addiction Therapy

Drug discrimination: stimulus control during repeated testing in extinction.

Rats were trained, under a two-lever drug-discrimination procedure, to respond differentially depending upon whether lorazepam (1.0 mg/kg) or no injection had been administered before the session. Responses on the appropriate lever produced a food pellet under a modified fixed-ratio (FR) 10 schedule, in which the 10 responses had to be emitted consecutively. In reinforcement tests, completing a...

Dose-response curve slope is a missing dimension in the analysis of HIV-1 drug resistance.

HIV-1 drug resistance is a major clinical problem. Resistance is evaluated using in vitro assays measuring the fold change in IC(50) caused by resistance mutations. Antiretroviral drugs are used at concentrations above IC(50), however, and inhibition at clinical concentrations can only be predicted from IC(50) if the shape of the dose-response curve is also known. Curve shape is influenced by c...

Saturated Vacua Interpolation along One Compact Dimension

A class of generalized Wess-Zumino models with distinct vacua is investigated. These models allow for BPS saturated vacua interpolation along one compact spatial dimension. The properties of these interpolations are studied.

On Operations Along the Generalization/Specialization Dimension

The need to derive a database schema from one or more existing schemas arises in Federated Database Systems as well as in other contexts. Operations used for this purpose include conforming operations, which change the form of a schema. In this paper we present a systematic approach to establish a set of primitive conforming operations that operate along the Generalization/Specialization dimens...